Endothelin-Induced Contraction and Relaxation of Rat Isolated Basilar Artery: Effect of BQ-123
Population
Ring segments from rat isolated basilar artery
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Suggests ETA antagonists may modulate cerebral vasomotor tone in models; leaves open translation to human cerebrovascular disease.
Structured PICO
P
Population
Ring segments from rat isolated basilar artery
I
Intervention
Endothelin peptides (ET-1, ET-2, ET-3) and selective ETA receptor antagonist BQ-123
O
Outcome
Vascular contraction and relaxationsurrogate
Endothelin-induced contraction in rat basilar arteries is mediated by ETA receptors, whereas ET-3 induces endothelium-dependent, NO-mediated relaxation.
Cite This Study
Feger et al. (1994) studied this question.