April 12, 2004AJP Heart and Circulatory Physiology

Endothelin-1-induced responses in isolated mouse vessels: the expression and function of receptor types

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Population

Isolated mouse vessels (abdominal aorta, thoracic aorta, carotid artery)

Design

Preclinical

Authors

YZYingbi ZhouShantou University WDWessel P. DirksenThe Ohio State University JZJay L. ZweíerCross-Cutting Cardiology

Discussion

Member takes

Implication

ET(A) selectivity should guide rodent aortic models; leaves open translation to human regional vasoreactivity.

Structured PICO

Population

Isolated mouse vessels (abdominal aorta, thoracic aorta, carotid artery)

Intervention

Endothelin-1 (ET-1) with or without NOS inhibitor l-NAME, ET(B) agonist sarafotoxin 6c (S6c), and ET(A) antagonist BQ-123

Outcome

Vascular responsiveness (isometric force measurements) and ET receptor expression (RT-PCR)surrogate

In mouse abdominal aorta, ET(A) receptors mediate potent vasoconstriction to ET-1, while ET(B) receptors have minimal functional presence, highlighting regional differences in vascular responsiveness.

Cite This Study

Zhou et al. (2004) studied this question.

synapsesocial.com/papers/6a8be880510c7253b5ded8f8 https://doi.org/10.1152/ajpheart.01170.2003

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Endothelin-1-induced responses in isolated mouse vessels: the expression and function of receptor types

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Endothelin-1-induced responses in isolated mouse vessels: the expression and function of receptor types

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider