September 1, 1990British Journal of PharmacologyOpen Access

Endothelium‐dependent vascular activities of endothelin‐like peptides in the isolated superior mesenteric arterial bed of the rat

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Population

Isolated Krebs-Henseleit perfused mesenteric arterial bed of the rat

Comparison

Endothelin-like peptides vs Control preparations

Design

Preclinical

Authors

SDStephen A. DouglasUniversity of Minnesota CHC. Robin HileyUniversity of Cambridge

Discussion

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Implication

Endothelium modulates endothelin-like peptide vasoconstriction in animal vessels; leaves open receptor subtype roles in human disease.

Structured PICO

Population

Isolated Krebs-Henseleit perfused mesenteric arterial bed of the rat

Intervention

Endothelin-like peptides (endothelin-1, endothelin-2, endothelin-3, sarafotoxin S6b, human proendothelin1-38, and mouse vasoactive intestinal contractor)

Comparator

Control preparations (presence vs. absence of endothelium, or presence of methylene blue or N omega-nitro-L-arginine methyl ester)

Outcome

Vasoconstrictor and vasodilator activities measured by changes in perfusion pressuresurrogate

The study demonstrates that the endothelium modulates the vascular effects of endothelin-like peptides, suggesting distinct receptor subtypes on vascular smooth muscle and endothelium.

Cite This Study

Douglas et al. (1990) studied this question.

synapsesocial.com/papers/6a8386e145d6ebe77211ab13 https://doi.org/10.1111/j.1476-5381.1990.tb12093.x

View Full Paper

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Bookmark

Endothelium‐dependent vascular activities of endothelin‐like peptides in the isolated superior mesenteric arterial bed of the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Endothelium‐dependent vascular activities of endothelin‐like peptides in the isolated superior mesenteric arterial bed of the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider