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July 1, 1960The Journal of General PhysiologyOpen Access

Increase of Labeled Calcium Uptake in Heart Muscle during Potassium Lack Contracture

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Why the study?

Does perfusion with K-free Ringer's solution increase labeled calcium uptake in isolated frog heart ventricles compared to normal Ringer's solution?

Population

Isolated frog heart ventricles

Comparison

Perfusion with K-free Ringer's solution vs Perfusion with normal Ringer's solution…

Design

Preclinical

Follow-up

Up to 3 hours of perfusion

Authors

LTLyell J. ThomasUniversity of Southern California

Discussion

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Implication

Associates Ca uptake with K-free contracture in frog ventricle; hypothesis-generating for mammalian cardiac Ca handling.

Structured PICO

Does perfusion with K-free Ringer's solution increase labeled calcium uptake in isolated frog heart ventricles compared to normal Ringer's solution?

P
Population
Isolated frog heart ventricles
I
Intervention
Perfusion with K-free Ringer's solution
C
Comparator
Perfusion with normal Ringer's solution containing 1 mM Ca
O
Outcome
Uptake of labeled Ca(45)surrogate

Potassium lack contracture in frog heart ventricles is associated with a significant increase in intracellular calcium uptake, suggesting calcium binding to sensitive intracellular sites causes the contracture.

Cite This Study

Lyell J. Thomas (1960) studied this question.

synapsesocial.com/papers/6a883697ab77196d53aa71f0https://doi.org/10.1085/jgp.43.6.1193
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