Population
Isolated Langendorff perfused rabbit hearts (37 degrees C)
Comparison
Calcium-free perfusion or low-calcium perfusion… vs Control values (normal calcium perfusion)
Design
Preclinical
Authors
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Reperfusion after calcium-free perfusion causes severe injury in isolated hearts; leaves open relevance to clinical ischemia-reperfusion injury.
Reperfusion with normal calcium after calcium-free perfusion in isolated rabbit hearts leads to severe cellular damage and massive creatine kinase release, characteristic of the calcium paradox.
Capucci et al. (1983) studied this question.
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