Population
Arterially perfused right ventricle of rabbit
Comparison
Electrical stimulation with extracellular… vs Rest periods / prestimulatory levels
Design
Preclinical
Authors
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Suggests rapid extracellular Ca²⁺ turnover per cycle in rabbit myocardium; leaves open relevance to human diastolic efflux and clinical calcium handling.
Most of the 'activator pool' of cellular calcium can turn over to the extracellular space during a single contraction cycle in rabbit myocardium, suggesting diastolic calcium efflux may be quantitatively negligible compared to efflux during excitation-contraction coupling.
Hilgemann et al. (1984) studied this question.
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