Key result
Norepinephrine or ionophore infusion elevates intracellular calcium and LV pressure in isolated rabbit hearts.
Population
Isolated, perfused rabbit hearts
Design
Preclinical
Authors
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Should not yet inform clinical contractility management; leaves open whether ionophore-driven calcium elevation via sodium exchange translates beyond rabbit models.
Fluorescent calcium indicators like quin2 can continuously measure intracellular calcium activity in intact organs, demonstrating that ionophores elevate calcium via sodium-calcium exchange independent of adrenergic receptors.
Lattanzio et al. (1986) studied this question. Norepinephrine, monensin, and salinomycin vs. Baseline or pretreatment with phentolamine and nadolol was evaluated on Intracellular calcium activity and left ventricular pressure. Infusion of norepinephrine or monovalent carboxylic ionophores elevated average intracellular calcium activity and left ventricular pressure in isolated rabbit hearts.
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