Why the study?
Does postischemic low Ca2+ perfusion improve metabolic and contractile recovery in isolated rat hearts?
Population
Isolated rat hearts
Comparison
Postischemic low Ca2+ perfusion during the first… vs Normal Ca2+ perfusion throughout reperfusion…
Design
Preclinical
Follow-up
30 minutes of reperfusion
Authors
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Low Ca2+ reperfusion may aid early recovery but triggers calcium paradox on reexposure; leaves open safe Ca2+ strategies for ischemic hearts.
Does postischemic low Ca2+ perfusion improve metabolic and contractile recovery in isolated rat hearts?
While postischemic low Ca2+ perfusion initially improves metabolic recovery, it enhances the susceptibility of the heart to the calcium paradox upon reexposure to normal calcium levels.
Kirkels et al. (1989) studied this question.
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