June 1, 1980AJP Heart and Circulatory Physiology

Effects of Ca2+ antagonism on energy metabolism: Ca2+ and heart function after ischemia

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Why the study?

Does verapamil improve mechanical function and energy metabolism in isolated rat hearts subjected to ischemia and reperfusion?

Population

Isolated rat hearts subjected to 25 min of ischemia

Comparison

Verapamil or low Ca2+-containing buffer… vs Control buffer only

Design

Preclinical

Authors

JWJohn A. WattsUniversity of North Carolina at Charlotte CKC KochNovartis (Switzerland)KLKathryn F. LaNouePenn State Milton S. Hershey Medical Center

Discussion

Member takes

Implication

Verapamil before ischemia preserves function in rat hearts; hypothesis-generating for timing of calcium blockade but leaves open clinical translation.

Structured PICO

Does verapamil improve mechanical function and energy metabolism in isolated rat hearts subjected to ischemia and reperfusion?

Population

Isolated rat hearts subjected to 25 min of ischemia

Intervention

Verapamil or low Ca2+-containing buffer administered during reperfusion, or verapamil present before and during ischemia

Comparator

Control buffer only

Outcome

Mechanical function, cellular calcium levels, and energy metabolites (nucleotides, ATP, creatine phosphate)surrogate

Verapamil improves recovery of function in ischemic rat hearts by decreasing energy demand during ischemia rather than by blocking calcium influx during reperfusion.

Cite This Study

Watts et al. (1980) studied this question.

synapsesocial.com/papers/6a868cfb7b9822affc8b8b17 https://doi.org/10.1152/ajpheart.1980.238.6.h909

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Implication

Verapamil before ischemia preserves function in rat hearts; hypothesis-generating for timing of calcium blockade but leaves open clinical translation.