Population
Isolated spontaneously beating rat hearts perfused in the Langendorff mode
Comparison
Hypoxia, ischemia, or ischemia followed by… vs Control (aerobic) perfusion
Design
Preclinical
Follow-up
90 minutes of perfusion
Authors
Loading...
Flow cessation, not hypoxia, drives sarcolemmal injury; leaves open ion-transport targeting in human ischemia.
Changes secondary to lack of flow rather than hypoxia play a major role in ischemic damage to the sarcolemmal membrane, which is not exacerbated by short-term reperfusion.
Daly et al. (1984) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: