November 1, 1987AJP Heart and Circulatory Physiology

Sarcolemmal Na+-Ca2+ exchange activity in hearts subjected to hypoxia reoxygenation

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Population

Isolated rat hearts

Comparison

Hypoxia followed by reoxygenation vs Control hearts

Design

Preclinical

Authors

IDIan DixonSt. Boniface Hospital DED. A. EyolfsonSt. Boniface Hospital NDNaranjan S. DhallaElectrophysiology

Discussion

Member takes

Implication

May contribute to Ca2+ overload in ischemia-reperfusion; hypothesis-generating for sarcolemmal targets in human cardioprotection.

Structured PICO

Population

Isolated rat hearts

Intervention

Hypoxia (perfusion with substrate-free medium gassed with 95% N2-5% CO2 for 10 min) followed by reoxygenation (reperfusion with oxygenated normal medium)

Comparator

Control hearts

Outcome

Sarcolemmal Na+-dependent Ca2+ uptake activity and ATP-dependent Ca2+ accumulationsurrogate

Hypoxia-reoxygenation induces defects in the sarcolemmal Na+-Ca2+ exchange system and ATP-dependent Ca2+ pump, which may contribute to intracellular Ca2+ overload and functional abnormalities.

Cite This Study

Dixon et al. (1987) studied this question.

synapsesocial.com/papers/6a830757b8819ff4224ccc39 https://doi.org/10.1152/ajpheart.1987.253.5.h1026

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Sarcolemmal Na+-Ca2+ exchange activity in hearts subjected to hypoxia reoxygenation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sarcolemmal Na+-Ca2+ exchange activity in hearts subjected to hypoxia reoxygenation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider