September 1, 1992Circulation Research
Dependence of hypoxic cellular calcium loading on Na(+)-Ca2+ exchange.
Population
Single electrically stimulated (0.2 Hz) adult rat cardiac myocytes
Comparison
Glucose-free hypoxia in Na-free buffer or with R… vs Normal Na(+)-containing buffer (144 mM NaCl)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypoxic cellular calcium loading and subsequent hypercontracture upon reoxygenation are linked to a rise in intracellular sodium via Na(+)-Ca2+ exchange.
Structured PICO
P
Population
Single electrically stimulated (0.2 Hz) adult rat cardiac myocytes
I
Intervention
Glucose-free hypoxia (PO2 < 0.02 mm Hg) in Na(+)-free buffer (144 mM choline chloride) or with R 56865
C
Comparator
Normal Na(+)-containing buffer (144 mM NaCl)
O
Outcome
Changes in intracellular sodium ([Na+]i) and calcium ([Ca2+]i) during hypoxia and reoxygenation, and cell hypercontracturesurrogate
Hypoxic cellular calcium loading and subsequent hypercontracture upon reoxygenation are linked to a rise in intracellular sodium via Na(+)-Ca2+ exchange.
Cite This Study
Haigney et al. (1992) studied this question.