Population
Isolated rat hearts
Comparison
Reperfusion after Ca2+ deprivation under various… vs Reperfusion with control medium
Design
Preclinical
Authors
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May inform experimental strategies to limit reperfusion ion imbalance; leaves open clinical translation in humans.
The study demonstrates that calcium overload during the calcium paradox is driven by the loss of calcium influx regulation during depletion, leading to irreversible myocardial damage.
Alto et al. (1979) studied this question.
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