Population
Isolated perfused rat hearts
Comparison
Monensin during 20 min-ischemia; or… vs Control hearts undergoing ischemia and…
Design
Preclinical
Authors
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Should not change clinical practice; hypothesis-generating and challenges Na+-Ca2+ exchange as sole mediator of reperfusion Ca2+ overload in this animal model.
The findings challenge the hypothesis that Na+ accumulation during ischemia and subsequent Na+-Ca2+ exchange is the primary mechanism for Ca2+ accumulation after reperfusion.
Kawada et al. (1992) studied this question.
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