June 4, 2007British Journal of PharmacologyOpen Access

Preservation of mitochondrial function may contribute to cardioprotective effects of Na+/Ca2+exchanger inhibitors in ischaemic/reperfused rat hearts

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Population

Isolated rat hearts subjected to 35-min ischaemia/60-min reperfusion or 20-min ischaemia/60-min reperfusion

Comparison

Na+/Ca2+ exchanger inhibitors given for 5 min… vs Untreated isolated rat hearts subjected to the…

Design

Preclinical

Follow-up

60 minutes of reperfusion

Authors

KMKanataka MotegiTokyo University of Pharmacy and Life Sciences KTKouichi TanonakaHeart Failure / Cardiomyopathy YTYuji TakenagaHokkaido Agricultural Research Center

Discussion

Member takes

Implication

NCX inhibition may aid cardioprotection in animal models; leaves open translation to human ischaemia/reperfusion injury.

Structured PICO

Population

Isolated rat hearts subjected to 35-min ischaemia/60-min reperfusion or 20-min ischaemia/60-min reperfusion

Intervention

Na+/Ca2+ exchanger (NCX) inhibitors (3-30 microM KB-R7943 or 0.3-1 microM SEA0400) given for 5 min prior to ischaemia (pre-ischaemic treatment) or for 10 min after the onset of reperfusion (post-ischaemic treatment)

Comparator

Untreated isolated rat hearts subjected to the same ischaemia/reperfusion protocols

Outcome

Post-ischaemic contractile recovery, Na+ accumulation, and damage to mitochondrial respiratory functionsurrogate

NCX inhibitors protect against mild ischaemia/reperfusion injury in rat hearts by preserving mitochondrial function and attenuating ion overload.

Cite This Study

Motegi et al. (2007) studied this question.

synapsesocial.com/papers/6a9513cc2fdd6c151ff21efb https://doi.org/10.1038/sj.bjp.0707321

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Preservation of mitochondrial function may contribute to cardioprotective effects of Na+/Ca2+exchanger inhibitors in ischaemic/reperfused rat hearts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Preservation of mitochondrial function may contribute to cardioprotective effects of Na+/Ca2+exchanger inhibitors in ischaemic/reperfused rat hearts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider