Population
Cross-circulated rat hearts subjected to 15 min global ischemia and 60 min reperfusion
Comparison
Na+/Ca2+ exchanger inhibitor KB-R7943 during… vs Control (no KBR)
Design
Preclinical
Follow-up
60 min reperfusion
Authors
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Supports reverse NCX inhibition in rat I/R models; leaves open translation to clinical reperfusion strategies.
Inhibition of reverse-mode Na+/Ca2+ exchange during initial reperfusion protects the rat heart against ischemia-reperfusion injury by preserving mechanical work and reducing proteolysis.
Hagihara et al. (2004) studied this question.
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