Key result
Calcium antagonists (verapamil, nifedipine, nitrendipine, nisoldipine, and diltiazem) abolished or attenuated the loss of noradrenaline caused by 15 minutes of ischaemia and reperfusion in rat hearts.
Why the study?
Do calcium antagonists reduce the amount of noradrenaline lost from the myocardium during periods of ischaemia and reperfusion in a rat model?
Population
Hearts obtained from adult, male, normotensive Sprague-Dawley rats
Comparison
Calcium antagonists vs Control hearts subjected to ischemia and…
Design
Preclinical
Authors
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Verapamil and diltiazem inhibit noradrenaline release in ischaemic rat hearts; leaves open clinical translation for cardioprotection.
Do calcium antagonists reduce the amount of noradrenaline lost from the myocardium during periods of ischaemia and reperfusion in a rat model?
Calcium antagonists attenuate the loss of myocardial noradrenaline during ischemia and reperfusion in a preclinical rat model.
Nayler et al. (1986) studied Ischaemic myocardium. Calcium antagonists (verapamil, nifedipine, nitrendipine, nisoldipine, diltiazem) vs. No calcium antagonist was evaluated on Loss of left ventricular noradrenaline (NA). Calcium antagonists (verapamil, nifedipine, nitrendipine, nisoldipine, and diltiazem) abolished or attenuated the loss of noradrenaline caused by 15 minutes of ischaemia and reperfusion in rat hearts.
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