Population
Isolated perfused rat hearts prelabelled with 3H-noradrenaline
Design
Preclinical
Follow-up
60 minutes of ischemia followed by reperfusion
Authors
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Noradrenaline washout on reperfusion may worsen injury; leaves open whether calcium-independent mechanisms warrant targeted therapies in human MI.
Myocardial ischemia induces early local release of noradrenaline, which is trapped in ischemic tissue and washed out during reperfusion independently of extracellular calcium.
Abrahamsson et al. (1985) studied this question.
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