Why the study?
Does ischemia induce early local release of noradrenaline in isolated rat hearts, and is it affected by perfusion substrates?
Population
Isolated, working rat hearts
Comparison
Ligation of the left coronary artery for 7.5 to… vs Different perfusion substrates
Design
Preclinical
Follow-up
Up to 30 minutes of ischemia followed by 5 minutes of…
Authors
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Early NA release after brief ischemia is substrate-modifiable in rat hearts; leaves open clinical translation and in vivo validation.
Does ischemia induce early local release of noradrenaline in isolated rat hearts, and is it affected by perfusion substrates?
Ischemia induces an early local release of noradrenaline in the isolated rat heart, a process that is modulated by the available metabolic substrates.
Carlsson et al. (1987) studied this question.
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