December 2, 1983European Heart Journal

Role of Na+-Ca2+ exchange in the development of cardiac abnormalities due to calcium paradox

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Population

Rat hearts subjected to calcium paradox

Comparison

Lowering the concentration of Na+ from 145 to 35… vs Standard Na+ concentration during Ca2+-free…

Design

Preclinical

Follow-up

1 to 10 minutes of reperfusion

Authors

NDN. S. DhallaLady Hardinge Medical College LAL. E. AltoUniversity of Manitoba PSPawan K. SingalHeart Failure / Cardiomyopathy

Discussion

Member takes

Implication

Intracellular Ca2+ overload during the calcium paradox is significantly mediated by Ca2+ entry through the Na+-Ca2+ exchange mechanism at the cell membrane.

Structured PICO

Population

Rat hearts subjected to calcium paradox (5 min perfusion with Ca2+-free medium followed by reperfusion with Ca2+-containing medium)

Intervention

Lowering the concentration of Na+ from 145 to 35 mmol l-1 in the medium during Ca2+-free perfusion or during the reperfusion phase

Comparator

Standard Na+ concentration (145 mmol l-1) during Ca2+-free perfusion and reperfusion

Outcome

Myocardial ultrastructure changes, high energy phosphate stores (creatine phosphate and ATP), microsomal and mitochondrial Ca2+ uptake activities, and cardiac Na+ and Ca2+ contentssurrogate

Intracellular Ca2+ overload during the calcium paradox is significantly mediated by Ca2+ entry through the Na+-Ca2+ exchange mechanism at the cell membrane.

Cite This Study

Dhalla et al. (1983) studied this question.

synapsesocial.com/papers/6a858e59581d4f62e2d5a9d0 https://doi.org/10.1093/eurheartj/4.suppl_h.51

Topics

Cardiomyopathy

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Implication

Intracellular Ca2+ overload during the calcium paradox is significantly mediated by Ca2+ entry through the Na+-Ca2+ exchange mechanism at the cell membrane.

Role of Na+-Ca2+ exchange in the development of cardiac abnormalities due to calcium paradox

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Role of Na+-Ca2+ exchange in the development of cardiac abnormalities due to calcium paradox

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider