Key result
Hypothermic Ca2+/Mg2+-free perfusion in isolated rat hearts significantly increased intracellular Na+ concentration (from 11.9 to 26.9 mM, P<0.001) without contributing to Ca2+ paradox damage.
Population
Isolated rat hearts
Comparison
Perfusion for 20 min with a Ca2+-free or a Ca2+… vs Normothermic Ca2+-free perfusion
Design
Preclinical
Follow-up
20 min
Authors
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Does not implicate Na+ in Ca2+ paradox injury; hypothesis-generating for ion-independent mechanisms in hypothermic cardioprotection.
p-value: p=< 0.001
An increase in intracellular Na+ during Ca2+ and Mg2+ depletion under hypothermic conditions does not contribute to Ca2+ paradox damage upon Ca2+ repletion in isolated rat hearts.
Jansen et al. (1998) studied Ca2+ paradox damage. Ca2+/Mg2+-free perfusion under hypothermic conditions vs. Ca2+-free perfusion or normothermic perfusion was evaluated on Intracellular Na+ concentration ([Na+]i) (p=< 0.001). Hypothermic Ca2+/Mg2+-free perfusion in isolated rat hearts significantly increased intracellular Na+ concentration (from 11.9 to 26.9 mM, P<0.001) without contributing to Ca2+ paradox damage.
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