December 2, 1983European Heart Journal

Diminished Na+/K+ and Ca2+ pump activities in the Ca2+ depleted heart: possible role in the development of Ca2+ overload during the Ca2+ paradox

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Population

Rabbit hearts

Design

Preclinical

Authors

LLLeida M. LamersInstitut für Forschung und Transfer TRT. J. C. RuigrokUtrecht University

Discussion

Member takes

Implication

Impaired Ca2+ extrusion may promote overload in the paradox; hypothesis-generating in animal models without clinical translation.

Structured PICO

Population

Rabbit hearts

Intervention

10 min of Ca2+-free perfusion (Ca2+ depletion)

Outcome

Biochemical properties of sarcolemma (SL) and sarcoplasmic reticulum (SR) including Ca2+ pumping rate and Na+/K+-ATPase activitysurrogate

Ca2+ depletion impairs the ability of the sarcolemma and sarcoplasmic reticulum to remove Ca2+ from the cytosol, contributing to Ca2+ overload during the Ca2+ paradox.

Cite This Study

Lamers et al. (1983) studied this question.

synapsesocial.com/papers/6a72403d3ce530166bc34897 https://doi.org/10.1093/eurheartj/4.suppl_h.73

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Diminished Na+/K+ and Ca2+ pump activities in the Ca2+ depleted heart: possible role in the development of Ca2+ overload during the Ca2+ paradox

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Diminished Na+/K+ and Ca2+ pump activities in the Ca2+ depleted heart: possible role in the development of Ca2+ overload during the Ca2+ paradox

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider