Population
Rabbit hearts
Comparison
Calcium-free perfusion and subsequent calcium… vs Control perfused hearts
Design
Preclinical
Authors
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May implicate Na+,K+-ATPase loss in calcium paradox injury; leaves open relevance to human myocardium or intact models.
Calcium depletion in rabbit hearts significantly reduces sarcolemmal Na+,K+-ATPase activity without altering Na+-Ca++ antiporter activity or passive calcium efflux, suggesting impaired calcium removal from the cytosol contributes to calcium paradox damage.
Lamers et al. (1984) studied this question.
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