August 1, 1982Circulation ResearchOpen Access

Calcium depletion in rabbit myocardium. Ultrastructure of the sarcolemma and correlation with the calcium paradox.

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Population

Vascularly perfused interventricular septum of the rabbit

Comparison

Ca-depletion via Ca-free and Ca-free plus EGTA… vs Control conditions

Design

Preclinical

Authors

JFJ. S. FrankUniversity of Southern California TRT. L. RichUniversity of California, Los Angeles SBS BeydlerUniversity of California, Los Angeles

Discussion

Member takes

Implication

Hypothermia prevents Ca depletion-induced sarcolemmal defects in rabbit myocardium; hypothesis-generating for human cardioprotection.

Structured PICO

Population

Vascularly perfused interventricular septum of the rabbit

Intervention

Ca-depletion via Ca-free and Ca-free plus EGTA perfusion at 28°C and 37°C, hypothermia (18°C), and Cd substitution

Comparator

Control conditions

Outcome

Ultrastructural changes in the sarcolemma (glycocalyx separation and intramembrane particle density/orientation)surrogate

Hypothermia completely prevents the ultrastructural sarcolemmal defects (glycocalyx separation and bilayer changes) induced by calcium depletion in rabbit myocardium.

Cite This Study

Frank et al. (1982) studied this question.

synapsesocial.com/papers/6a7151fac92390ac2d07ef2a https://doi.org/10.1161/01.res.51.2.117

View Full Paper

Ask AI

Bookmark

Calcium depletion in rabbit myocardium. Ultrastructure of the sarcolemma and correlation with the calcium paradox.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Calcium depletion in rabbit myocardium. Ultrastructure of the sarcolemma and correlation with the calcium paradox.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider