Key result
Potassium contracture in contracting frog twitch muscle fibers produced a calcium uptake of 6.7 pmol versus 3.0 pmol in paralyzed fibers, with a paired difference of 2.9 pmol related to contraction.
Population
Isolated frog twitch muscle fibers
Comparison
Potassium contracture in the presence of 30… vs Fibers paralyzed by the combination of 30 microM…
Design
Preclinical
Authors
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Hypothesis-generating for contraction-linked Ca²⁺ handling in amphibian muscle; leaves open relevance to mammalian cardiac physiology.
Mean Difference: 2.9
Absolute Event Rate: 6.7% vs 3%
In frog twitch muscle fibers, a delayed component of calcium uptake is related to contraction, likely representing a reflux refilling a binding site emptied during the prior contracture.
Curtis et al. (1985) studied Isolated frog twitch muscle fibers. Potassium contracture vs. Paralyzed fibers (30 microM D600, cold, prior contracture) was evaluated on Calcium uptake (pmol in 0.7 cm of fiber) (Paired difference 2.9 pmol). Potassium contracture in contracting frog twitch muscle fibers produced a calcium uptake of 6.7 pmol versus 3.0 pmol in paralyzed fibers, with a paired difference of 2.9 pmol related to contraction.
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