Population
Isotopically labeled frog skeletal muscle fibers
Design
Preclinical
Authors
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Does not inform clinical calcium handling in human heart; leaves open translation of thin-filament localization to mammalian cardiac models.
This basic science study demonstrates that during tetanus in frog skeletal muscle, calcium localizes primarily to the thin filaments, and its post-tetanic movement within the reticulum has a half-time of approximately 9 seconds.
Saul Winegrad (1970) studied this question.
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