June 1, 1985Journal of Biological ChemistryOpen Access

Electron probe X-ray microanalysis of post-tetanic Ca2+ and Mg2+ movements across the sarcoplasmic reticulum in situ.

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Population

Frog skeletal muscle fibers

Comparison

Tetanic stimulation vs Resting levels

Design

Preclinical

Follow-up

Up to 1.1 seconds post-tetanus

Authors

ASA V SomlyoUniversity of Virginia GMG McClellanUniversity of Maryland, Baltimore HGH Gonzalez‐SerratosUniversity of Maryland, Baltimore

Discussion

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Implication

Supports SR Ca-ATPase sufficiency for skeletal relaxation; hypothesis-generating for cardiac Ca2+ kinetics.

Structured PICO

Population

Frog skeletal muscle fibers

Intervention

Tetanic stimulation (1.2-s tetanus at room temperature)

Comparator

Resting levels

Outcome

Ca2+ and Mg2+ movements across the sarcoplasmic reticulum in situsurrogate

The in situ pumping of the SR Ca-ATPase is sufficiently high to account for the rate of relaxation from a tetanus, with Ca2+ return likely rate-limited by its off-rate from parvalbumin.

Cite This Study

Somlyo et al. (1985) studied this question.

synapsesocial.com/papers/6a709d6926a7f98052dd16c4 https://doi.org/10.1016/s0021-9258(18)88850-0

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Electron probe X-ray microanalysis of post-tetanic Ca2+ and Mg2+ movements across the sarcoplasmic reticulum in situ.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Electron probe X-ray microanalysis of post-tetanic Ca2+ and Mg2+ movements across the sarcoplasmic reticulum in situ.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider