Population
Voltage-clamped frog skeletal muscle fibers (n=4 cells for steady release permeability measurement)
Comparison
Clamp depolarization with progressive reduction… vs Resting sarcoplasmic reticulum Ca2+ content
Design
Preclinical
Authors
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Indicates cytosolic Ca²⁺ inhibition of release channels; extends skeletal muscle mechanisms but leaves open cardiac translation.
In frog skeletal muscle fibers, depletion of sarcoplasmic reticulum calcium increases steady calcium release permeability and slows its inactivation, suggesting a major inhibitory effect of cytosolic calcium on release channels.
Pizarro et al. (2004) studied this question.
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