Key result
Voltage clamp depolarization of rat skeletal muscle fibres elicited elementary Ca2+ release events (amplitude 0.19, spatial half-width 1.3 microm), likely reflecting single RyR channel openings.
Population
Rat skeletal muscle fibres
Design
Preclinical
Authors
Loading...
Elementary Ca2+ events in rat skeletal muscle may reflect single RyR openings; leaves open their contribution to cardiac Ca2+ sparks.
Elementary fluorescence events in rat skeletal muscle elicited by depolarization likely reflect the opening of a single RyR channel, with global Ca2+ release flux resulting from the summation of these discrete events.
Csernoch et al. (2004) studied this question. Voltage clamp depolarization was evaluated on Elementary events of Ca2+ release. Voltage clamp depolarization of rat skeletal muscle fibres elicited elementary Ca2+ release events (amplitude 0.19, spatial half-width 1.3 microm), likely reflecting single RyR channel openings.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: