September 30, 1997Proceedings of the National Academy of SciencesOpen Access

Voltage dependence of the pattern and frequency of discrete Ca 2+ release events after brief repriming in frog skeletal muscle

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Population

Frog skeletal muscle fibers

Comparison

Depolarizing test pulses after a brief… vs Different test pulse voltages

Design

Preclinical

Authors

MKMichael G. KleinPacific Northwest National Laboratory ALAlain LacampagneElectrophysiology MSMartin F. SchneiderFriedrich-Alexander-Universität Erlangen-Nürnberg

Discussion

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Implication

Refines models of skeletal muscle Ca2+ release; leaves open applicability to cardiac muscle or in vivo conditions.

Structured PICO

Population

Frog skeletal muscle fibers

Intervention

Depolarizing test pulses after a brief repolarizing pre-pulse

Comparator

Different test pulse voltages

Outcome

Frequency, pattern, latency, mean use time, and mean amplitude of discrete Ca2+ release events (sparks)surrogate

This study demonstrates that the voltage dependence of sarcoplasmic reticulum calcium release in skeletal muscle is driven by the frequency and pattern of discrete release events rather than changes in individual channel open times or conductances.

Cite This Study

Klein et al. (1997) studied this question.

synapsesocial.com/papers/6a761454cd662f67b2fbd87b https://doi.org/10.1073/pnas.94.20.11061

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Voltage dependence of the pattern and frequency of discrete Ca 2+ release events after brief repriming in frog skeletal muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Voltage dependence of the pattern and frequency of discrete Ca 2+ release events after brief repriming in frog skeletal muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider