December 15, 1996The Journal of PhysiologyOpen Access

Repriming and activation alter the frequency of stereotyped discrete Ca2+ release events in frog skeletal muscle.

View Full Paper

Ask AI

Bookmark

Population

Voltage-clamped frog skeletal muscle fibres

Comparison

Repriming pulse followed by depolarization to 0 mV vs Different repriming times; small depolarizations…

Design

Preclinical

Authors

ALAlain LacampagneElectrophysiology WLW. J. LedererUniversity of Maryland, Baltimore MSMartin F. SchneiderFriedrich-Alexander-Universität Erlangen-Nürnberg

Discussion

Member takes

Implication

Frequency grades SR Ca2+ release amplitude in frog muscle; extends spark models but leaves open mammalian cardiac translation.

Structured PICO

Population

Voltage-clamped frog skeletal muscle fibres

Intervention

Repriming pulse (repolarization to -90 mV) followed by depolarization to 0 mV

Comparator

Different repriming times; small depolarizations of fibres held at -90 mV

Outcome

Frequency, amplitude, and spatio-temporal extent of Ca2+ sparkssurrogate

The amplitude of sarcoplasmic reticulum Ca2+ release in frog skeletal muscle is graded by the frequency, rather than the amplitude or spatio-temporal extent, of individual Ca2+ sparks.

Cite This Study

Lacampagne et al. (1996) studied this question.

synapsesocial.com/papers/6a7e8ea8e9bb045a73c2f9c5 https://doi.org/10.1113/jphysiol.1996.sp021791

View Full Paper

Ask AI

Bookmark

Repriming and activation alter the frequency of stereotyped discrete Ca2+ release events in frog skeletal muscle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Repriming and activation alter the frequency of stereotyped discrete Ca2+ release events in frog skeletal muscle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider