March 1, 1996Acta Physiologica Scandinavica

Mechanisms underlying changes of tetanic [Ca²⁺]i and force in skeletal muscle

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Population

Intact, single fibres from mouse and Xenopus skeletal muscles

Design

Preclinical

Authors

HWHåkan WesterbladHeart Failure / Cardiomyopathy DADavid G. AllenUniversity of North Carolina at Chapel Hill

Discussion

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Implication

Hypothesis-generating for Ca2+-myofibrillar interactions in fatigue; requires validation in human cardiac models before any clinical inference.

Structured PICO

Population

Intact, single fibres from mouse and Xenopus skeletal muscles

Intervention

Various interventions including beta-adrenergic stimulation, 2.5-di(tert-butyl)-1,4-benzohydroquinone, caffeine, early/late fatigue, acidosis, and alkalosis

Outcome

Tetanic myoplasmic free [Ca2+]i and force developmentsurrogate

This preclinical study elucidates the complex interplay between sarcoplasmic reticulum calcium handling, myoplasmic buffering, and myofibrillar sensitivity in determining skeletal muscle force under various physiological and pharmacological conditions.

Cite This Study

Westerblad et al. (1996) studied this question.

synapsesocial.com/papers/6a8293b7e0918b5470d10e4c https://doi.org/10.1046/j.1365-201x.1996.196000.x

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Implication

Hypothesis-generating for Ca2+-myofibrillar interactions in fatigue; requires validation in human cardiac models before any clinical inference.

Mechanisms underlying changes of tetanic [Ca²⁺]i and force in skeletal muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanisms underlying changes of tetanic [Ca²⁺]i and force in skeletal muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider