Population
Single fibres isolated from the anterior tibialis muscle of Rana temporaria
Comparison
Fatigue and intracellular acidification vs Control state (300 s between tetani)
Design
Preclinical
Authors
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Implicates reduced force per cross-bridge in isolated-fiber fatigue; leaves open relevance to human cardiac muscle.
Fatigue-induced decreases in contractile strength in frog muscle fibers are likely due to altered cross-bridge kinetics leading to reduced force output per bridge, rather than just fewer active cross-bridges.
Edman et al. (1990) studied this question.
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