Population
Single fibres from the anterior tibialis muscle of frogs
Comparison
Fatigue and intracellular acidification vs Normal conditions (unfatigued, normal pH)
Design
Preclinical
Authors
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Findings in frog fibers should not change clinical practice; extends fatigue mechanisms but leaves human translation open.
Fatigue and intracellular acidification reduce tetanus force and prolong the linear phase of force decline, leading to more uniform segment behavior during relaxation in frog muscle fibers.
Curtin et al. (1989) studied this question.
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