Key result
Fatigue produced by repeated tetani in single mouse muscle fibers is caused by reduced maximum tension-generating capacity, reduced myofibrillar Ca2+ sensitivity, and reduced Ca2+ release.
Population
Intact, single muscle fibers dissected from a mouse foot muscle and loaded with fura-2
Comparison
Fatiguing stimulation produced by repeated… vs Control conditions
Design
Preclinical
Authors
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Fatigue proceeds in three phases with early tetanic [Ca2+]i rise; extends models of Ca2+ handling during repeated contractions.
In mouse skeletal muscle fibers, fatigue from repeated tetani involves early depression of maximum tension-generating capacity followed by reduced Ca2+ sensitivity and release.
Westerblad et al. (1991) studied Muscle fatigue. Fatiguing stimulation (repeated 100-Hz tetani) vs. Control conditions was evaluated on Intracellular free concentration of Ca2+ ([Ca2+]i) and tension. Fatigue produced by repeated tetani in single mouse muscle fibers is caused by reduced maximum tension-generating capacity, reduced myofibrillar Ca2+ sensitivity, and reduced Ca2+ release.
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