Key result
During fatiguing stimulation of isolated Xenopus muscle fibres, tetanic tension declined steadily while peak intracellular calcium initially increased to 155% of control before falling to 14%.
In isolated Xenopus muscle fibers, fatigue is associated with a substantial decline in intracellular calcium transients, which can explain the reduction in tension at the end of fatiguing stimulation.
No takes yet. Share an insight, caveat, or question.
May explain late tension loss in this isolated-fiber model; leaves open calcium's role in mammalian muscle fatigue in vivo.
Allen et al. (1989) studied this question. Fatiguing stimulation and CO2 exposure vs. Initial control/unfatigued state was evaluated on Intracellular calcium concentration and tension. During fatiguing stimulation of isolated Xenopus muscle fibres, tetanic tension declined steadily while peak intracellular calcium initially increased to 155% of control before falling to 14%.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: