What question did this study set out to answer?

To review the bioenergetics, electrogenic properties, and membrane transport mechanisms governing calcium turnover by the sarcoplasmic reticulum during skeletal muscle activity.

October 1, 1983Annual Review of Physiology

Energetics and Electrogenicity of the Sarcoplasmic Reticulum Calcium Pump

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Authors

WHW. HasselbachGoethe University Frankfurt HOH. OetlikerKantonsspital St. Gallen

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Implication

Synthesizes skeletal muscle SR calcium energetics; leaves open cardiac translation and clinical relevance in heart disease.

Key Points

To review the bioenergetics, electrogenic properties, and membrane transport mechanisms governing calcium turnover by the sarcoplasmic reticulum during skeletal muscle activity.
Synthesized physiological and biophysical literature evaluating sarcoplasmic reticulum calcium distribution, turnover kinetics, and surface-to-volume parameters.
Assessed thermodynamic models describing the transformation of chemical energy into osmotic gradients during muscle excitation-contraction cycles.
Free myoplasmic calcium levels transition from 50 nM at rest to 5 µM during contraction, while internal sarcoplasmic reticulum concentration is maintained at 0.5–2.0 mM against a 1:10,000 to 1:100,000 gradient.
Each activation-relaxation cycle demands rapid release and recapture of approximately 200 nmol of calcium per gram of muscle across a membrane area of 2 m² per gram.
Calcium reuptake and resting gradient maintenance drive a substantial proportion of overall skeletal muscle metabolic energy expenditure.

Cite This Study

Hasselbach et al. (1983) studied this question.

synapsesocial.com/papers/6a85151b39166d68e0e59598 https://doi.org/10.1146/annurev.ph.45.030183.001545

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Energetics and Electrogenicity of the Sarcoplasmic Reticulum Calcium Pump

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Cite This Study

Energetics and Electrogenicity of the Sarcoplasmic Reticulum Calcium Pump

Discussion

Member takes

Implication

Key Points

Cite This Study

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