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October 1, 1984Physiological Reviews

Mechanisms of Ca2+ release from sarcoplasmic reticulum of skeletal muscle

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AMA. MartonosiState University of New York

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Overview

Leaves open key mechanistic gaps in skeletal muscle Ca2+ release; directs future basic research without clinical translation.

Key Points

  • This research aims to elucidate the mechanisms underlying Ca2+ release from the sarcoplasmic reticulum and its role in muscle function.
  • Analysis of ATP-dependent Ca2+ transport kinetics from the sarcoplasmic reticulum.
  • Study of charge movement in excitation-contraction coupling.
  • Investigation of structural and functional characteristics of the T-SR junction.
  • Identified Ca2+-induced Ca2+ release as a significant mechanism for physiological Ca2+ release.
  • Outlined major unresolved issues including Ca2+ translocation across membranes and coupling to ATP hydrolysis.
  • Highlighted the importance of protein interactions in regulating calcium transport and permeability.

Cite This Study

A. Martonosi (1984) studied this question.

synapsesocial.com/papers/6a7699b22e130d02afec12f0https://doi.org/10.1152/physrev.1984.64.4.1240
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanism of Ca 2+ Transport by Sarcoplasmic Reticulum1983
  2. 2Molecular mechanism of calcium uptake and release by cardiac sarcoplasmic reticulum.1990 · 10 citations
  3. 3Another trigger for the heartbeat1998 · 4 citations
  4. 4The Ca2+‐ATPase of the Sarcoplasmic Reticulum in Skeletal and Cardiac Muscle: An Overview from the Very Beginning to More Recent Prospects1998 · 11 citations
  5. 5Excitation‐contraction coupling in the heart: the state of the question 11992 · 85 citations