Population
Heart cells (basic science review of excitation-contraction coupling)
Design
Review
Key result
Theoretical modeling suggests that locating sarcolemmal calcium channels in close proximity to sarcoplasmic reticulum release channels can resolve the positive feedback paradox in the heart.
Authors
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Graded Ca²⁺ release challenges binary CICR models; leaves open voltage-channel coupling mechanisms for further study.
This review proposes that the ultrastructural arrangement of calcium channels resolves the paradox of graded calcium-induced calcium release in cardiac excitation-contraction coupling.
Stern et al. (1992) conducted a review in Excitation-contraction coupling in the heart. Calcium-induced calcium release mechanism was evaluated. Theoretical modeling suggests that locating sarcolemmal calcium channels in close proximity to sarcoplasmic reticulum release channels can resolve the positive feedback paradox in the heart.
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