This review proposes that the ultrastructural arrangement of calcium channels resolves the paradox of graded calcium-induced calcium release in cardiac excitation-contraction coupling.
Graded Ca²⁺ release challenges binary CICR models; leaves open voltage-channel coupling mechanisms for further study.
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Stern et al. (1992) conducted a review in Excitation-contraction coupling in the heart. Calcium-induced calcium release mechanism was evaluated.
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