Population
Mammalian cardiac muscle (multicellular preparations and isolated myocytes)
Design
Review
Key result
The sarcolemmal Na/Ca exchanger may generate an initial spike of calcium entry sufficient to trigger sarcoplasmic reticular calcium release, challenging the view that L-type channels are the sole trigger.
Authors
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Challenges L-type exclusivity in EC coupling models; hypothesis-generating for Na/Ca exchanger role, needing in vivo validation before any clinical shift.
This review proposes that the sarcolemmal Na/Ca exchanger directly triggers calcium release from the sarcoplasmic reticulum during cardiac muscle depolarization, challenging the paradigm that L-type calcium channels are the exclusive trigger.
Levi et al. (1993) conducted a review in Cardiac muscle physiology. Na/Ca exchanger-mediated calcium entry vs. L-type calcium channels was evaluated. The sarcolemmal Na/Ca exchanger may generate an initial spike of calcium entry sufficient to trigger sarcoplasmic reticular calcium release, challenging the view that L-type channels are the sole trigger.