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February 14, 1992Science

Gating of the Cardiac Ca 2+ Release Channel: the Role of Na + Current and Na + -Ca 2+ Exchange

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Population

Cardiac myocytes

Design

Preclinical

Authors

JSJames S.K. ShamLCLars Nilausen CleemannMMMartin Morad

Discussion

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Overview

No immediate clinical implications for myocyte calcium handling; leaves open translation of calcium-channel primacy to human physiology.

Structured PICO

P
Population
Cardiac myocytes
I
Intervention
Suppression of sodium current by reducing external sodium concentration or applying tetrodotoxin
O
Outcome
Calcium release from the sarcoplasmic reticulumsurrogate

This study demonstrates that calcium influx through the calcium channel, rather than sodium current or sodium-calcium exchange, is the primary trigger for fast calcium release from the sarcoplasmic reticulum in cardiac myocytes.

Cite This Study

Sham et al. (1992) studied this question.

synapsesocial.com/papers/6a70a8cfaf0c21e939286e6fhttps://doi.org/10.1126/science.1311127
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