May 19, 1989Science

Regulation of Calcium Release Is Gated by Calcium Current, Not Gating Charge, in Cardiac Myocytes

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Population

Rat ventricular myocytes

Design

Preclinical

Authors

MNMichael NäbauerInterventional / Structural Cardiology GCGeert CallewaertVlakwa LCLars Nilausen CleemannMoesgaard Museum

Discussion

Member takes

Implication

Reinforces calcium-induced calcium release in cardiac myocytes; extends mechanistic models but leaves open human translation.

Structured PICO

Population

Rat ventricular myocytes

Intervention

Rapid exchange (20 to 50 milliseconds) of extracellular solutions

Outcome

Intracellular calcium transients or cell shorteningsurrogate

This study establishes that calcium influx through calcium channels, rather than intramembrane charge movement, gates calcium release from the sarcoplasmic reticulum in cardiac muscle.

Cite This Study

Näbauer et al. (1989) studied this question.

synapsesocial.com/papers/6a20798acbc595e190318128 https://doi.org/10.1126/science.2543067

View Full Paper

Ask AI

Bookmark

Regulation of Calcium Release Is Gated by Calcium Current, Not Gating Charge, in Cardiac Myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulation of Calcium Release Is Gated by Calcium Current, Not Gating Charge, in Cardiac Myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider