What question did this study set out to answer?

To outline the activation pathways and intracellular calcium release mechanisms responsible for excitation-contraction coupling in vertebrate skeletal muscle.

February 1, 1991Quarterly Reviews of Biophysics

Ca2+and activation mechanisms in skeletal muscle

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Population

vertebrate striated muscle fibres

Design

Review

Authors

CAChristopher AshleyAlbany Stratton VA Medical Center Albany IMI. P. MulliganJohn Radcliffe Hospital TLT. J. LeaUniversity of Oxford

Discussion

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Implication

Informs biophysical models of contraction; leaves open extension to cardiac SR calcium handling in disease.

Key Points

To outline the activation pathways and intracellular calcium release mechanisms responsible for excitation-contraction coupling in vertebrate skeletal muscle.
Synthesized physiological and structural evidence defining vertebrate striated muscle activation.
Evaluated the spatial and functional relationships between the surface membrane, transverse tubular system, and sarcoplasmic reticulum storage sites.
Excitation-contraction coupling relies primarily on calcium ions released from internal stores in the terminal cisternae of the sarcoplasmic reticulum.
Electrical excitation spreads from the surface membrane through the transverse tubular system to activate calcium release sites located adjacent to contractile myofibrils.

Structured PICO

Population

vertebrate striated muscle fibres

Describes the fundamental role of calcium ions and the sarcoplasmic reticulum in skeletal muscle excitation-contraction coupling.

Cite This Study

Ashley et al. (1991) studied this question.

synapsesocial.com/papers/6a71470efebe604dd709f8c3 https://doi.org/10.1017/s0033583500003267

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Ca2+and activation mechanisms in skeletal muscle

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Ca2+and activation mechanisms in skeletal muscle

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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