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August 1, 1976The Journal of PhysiologyOpen Access

Calcium conductance in relation to contractility in frog myocardium.

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Population

Frog atrial muscle

Design

Preclinical

Authors

MHM HoráckováDalhousie UniversityGVGuy VassortElectrophysiology

Discussion

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Overview

No immediate clinical implications; leaves open whether Ca current directly triggers contraction in mammalian or human myocardium.

Structured PICO

P
Population
Frog atrial muscle
I
Intervention
Voltage-clamp conditions in Na-free (Li) Ringer solution with tetrodotoxin (TTX) added
O
Outcome
Relationship between Ca inward current and the corresponding phasic component of tensionsurrogate

In frog myocardium, calcium inward current directly activates phasic contraction, and normal repolarization depends mainly on the decay of this calcium current.

Cite This Study

Horácková et al. (1976) studied this question.

synapsesocial.com/papers/6a70d7dac1a24a6142db98bbhttps://doi.org/10.1113/jphysiol.1976.sp011485
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The relation between membrane potential, membrane currents and activation of contraction in ventricular myocardial fibres1970 · 302 citations
  2. 2Membrane calcium current in ventricular myocardial fibres1970 · 399 citations
  3. 3Kinetic analysis of the delayed outward currents in frog atrium. Existence of two types of preparation1974 · 44 citations
  4. 4Membrane Currents in Mammalian Ventricular Heart Muscle Fibers Using a Voltage-Clamp Technique1971 · 64 citations
  5. 5Calcium Requirements for Cardiac Myofibrillar Activation1974 · 167 citations