January 1, 1981The Journal of PhysiologyOpen Access

The tension‐depolarization relationship of frog atrial trabeculae as determined by potassium contractures.

View Full Paper

Ask AI

Bookmark

Population

Isolated frog atrial trabeculae

Comparison

Potassium contractures under varying… vs Different ionic and pharmacological conditions

Design

Preclinical

Authors

RCReg ChapmanUniversity of Arizona JTJ. TunstallUniversity of Leicester

Discussion

Member takes

Implication

Hypothesis-generating for Na+/Ca2+ exchange in atrial tone; leaves open translation to mammalian myocardium.

Structured PICO

Population

Isolated frog atrial trabeculae

Intervention

Potassium contractures under varying extracellular ionic conditions (Na+, Ca2+) and pharmacological agents (Mn ions, D600, tetracaine)

Comparator

Different ionic and pharmacological conditions

Outcome

Tension-depolarization relationship (phasic and tonic contractile responses)surrogate

This basic science study elucidates the distinct mechanisms underlying phasic and tonic contractile responses in frog atrial tissue, highlighting the role of Na+/Ca2+ exchange in tonic tension.

Cite This Study

Chapman et al. (1981) studied this question.

synapsesocial.com/papers/6a6f25793ce530166bc29409 https://doi.org/10.1113/jphysiol.1981.sp013539

View Full Paper

Ask AI

Bookmark

The tension‐depolarization relationship of frog atrial trabeculae as determined by potassium contractures.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The tension‐depolarization relationship of frog atrial trabeculae as determined by potassium contractures.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider