Population
Isolated frog atrial trabeculae
Comparison
Reduction of bathing sodium concentration ([Na]o) vs Normal sodium concentration or varying [Ca]o /…
Design
Preclinical
Authors
Loading...
Does not inform clinical care; hypothesis-generating for Na+-dependent Ca2+ influx mechanisms in cardiac muscle.
This basic science study suggests that the influx of Ca2+ which induces Na-free contracture in frog atrial trabeculae depends on the presence of intracellular Na+.
Reg Chapman (1974) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: