Population
Frog atrial trabeculae
Comparison
Caffeine exposure in Na-poor solutions with… vs Low-Na contractures; varying ionic…
Design
Preclinical
Authors
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Does not inform clinical Ca2+ handling; leaves open whether Na/Ca exchange competition modulates contractility in mammalian hearts.
The study demonstrates that in frog cardiac muscle, the strength of caffeine-induced contracture is determined by competition between contractile proteins and the Na/Ca exchanger for intracellularly released calcium.
Chapman et al. (1983) studied this question.
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