January 1, 1962The Japanese Journal of PhysiologyOpen Access

Studies on the Mechanism of the Excitationcon-Traction Coupling in Cardiac Muscle, With Special Reference to the Caffeine-Contracture

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Population

Frog cardiac ventricular strips

Comparison

Caffeine in normal Ringer solution… vs Normal Ringer solution without caffeine, or…

Design

Preclinical

Authors

KSKeishi SuzukiHarvard University

Discussion

Member takes

Implication

Animal data suggest context-specific caffeine effects on cardiac muscle; leaves open relevance to mammalian excitation-contraction coupling or clinical use.

Structured PICO

Population

Frog cardiac ventricular strips

Intervention

Caffeine (5-50mM) in normal Ringer solution, sodium-deficient Ringer solution, and calcium-free medium

Comparator

Normal Ringer solution without caffeine, or varying concentrations of sodium and calcium

Outcome

Contractility, automaticity, resting potential, action potential duration, and induction of contracturesurrogate

Caffeine induces contracture in frog ventricular strips only under conditions of sodium deficiency and calcium presence, providing insights into the mechanism of excitation-contraction coupling.

Cite This Study

Keishi Suzuki (1962) studied this question.

synapsesocial.com/papers/6a883541af2c2bd0114dec14 https://doi.org/10.2170/jjphysiol.12.186

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Implication

Animal data suggest context-specific caffeine effects on cardiac muscle; leaves open relevance to mammalian excitation-contraction coupling or clinical use.

Studies on the Mechanism of the Excitationcon-Traction Coupling in Cardiac Muscle, With Special Reference to the Caffeine-Contracture

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Studies on the Mechanism of the Excitationcon-Traction Coupling in Cardiac Muscle, With Special Reference to the Caffeine-Contracture

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider