Population
Trabecular muscle fibers dissected from the inner surface of the atrium of the bullfrog, Rana catesbeiana.
Comparison
Caffeine applied after exposure to a Ca-rich… vs Standard Ringer solution or varying…
Design
Preclinical
Authors
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Animal data on frog cardiac muscle leave open caffeine-sensitive Ca release mechanisms in mammals; hypothesis-generating for excitation-contraction studies.
Caffeine induces a biphasic contracture in frog cardiac muscle after exposure to high calcium, with the initial transient phase likely related to internal calcium release.
MATSUMURA et al. (1980) studied this question.
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