August 1, 1980The Journal of PhysiologyOpen Access

The interaction of sodium and calcium ions at the cell membrane and the control of contractile strength in frog atrial muscle.

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Population

Isolated frog trabeculae (atrial muscle)

Comparison

Varying levels of bathing potassium and calcium… vs Different concentrations of bathing ions

Design

Preclinical

Authors

RCReg ChapmanUniversity of Arizona JTJ. TunstallUniversity of Leicester

Discussion

Member takes

Implication

Does not inform clinical ion handling; leaves open NCX stoichiometry confirmation in mammalian myocardium.

Structured PICO

Population

Isolated frog trabeculae (atrial muscle)

Intervention

Varying levels of bathing potassium (K) and calcium (Ca) ions, and experimental manoeuvres to increase intracellular sodium ([Na]i), combined with lowering bathing sodium ([Na]o)

Comparator

Different concentrations of bathing ions

Outcome

Contracture tensionsurrogate

This preclinical study provides evidence that the sodium-calcium exchange in frog atrial muscle likely operates at a stoichiometry of 3 Na+ to 1 Ca2+.

Cite This Study

Chapman et al. (1980) studied this question.

synapsesocial.com/papers/6a7ea11c061146f178a6c409 https://doi.org/10.1113/jphysiol.1980.sp013353

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The interaction of sodium and calcium ions at the cell membrane and the control of contractile strength in frog atrial muscle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The interaction of sodium and calcium ions at the cell membrane and the control of contractile strength in frog atrial muscle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider